HORDB

ID: hor005766
Uniprot ID: P01289
Protein name: Neuropeptide gamma
Gene name: TAC1
Organism: Bos taurus (Bovine)
Family: Tachykinin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0031835 substance P receptor binding
GO BP: GO:0006954 inflammatory response; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0019233 sensory perception of pain; GO:0048265 response to pain
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030424 axon; GO:0043025 neuronal cell body; GO:0045202 synapse

Sequence: GHGQLSHKRHKTDSFVGLM
Length: 19(89-107)
Propeptide: MKILVAVAVIFFISTQLSAEEIGANDDFNYWSDWSDSDQIKEEMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQLSHKRHKTDSFVGLMGKRALNSVAYERSVMQDYERRRK
Signal peptide: MKILVAVAVIFFISTQLSA
Modification: T19 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Mechanism: NA
Cross BBB: NA
Target: TACR1, TACR2
Target Unid: F1MIX5, P05363
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005766_AF2.pdb

hor005766_ESM.pdb

Mass:	245668	Formula:	C92H147N31O26S
Absent amino acids:	ACEINPWY	Common amino acids:	GH
pI:	10.79	Basic residues:	6
Polar residues:	6	Hydrophobic residues:	4
Hydrophobicity:	-83.68	Boman Index:	-4160
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	56.32
Instability Index:	6190.53	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 6195531
Title: Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor.
PubMed ID: 6083453
Title: Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing.
PubMed ID: 1708336
Title: Tachykinin (substance-P) gene expression in Leydig cells of the
PubMed ID: 2809597
Title: